Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer - download pdf or read online

By Michael B. Sawyer, Catherine J. Field (auth.), Gabriella Calviello, Simona Serini (eds.)

ISBN-10: 9048135788

ISBN-13: 9789048135783

Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer presents the entire newest details at the attainable advantages of omega-3 polyunsaturated fatty acids (PUFAs) opposed to a large sequence of cancers.

Several influential scientists during this box have contributed to make this publication an precise one among the others released thus far during this box. The chapters supply distinct information regarding the consequences acquired during this box via experimental reviews performed on either animals and cultured cells, in addition to via human intervention trials and epidemiological observational stories. This booklet represents a major device for researchers operating in food and oncology, because it collects all of the wisdom approximately omega-3 PUFAs and melanoma, even the newest, in one booklet. For the 1st time controversies one of the diversified reviews also are coated with nice information during this ebook.

The publication makes physicians in a position to basically comprehend on a systematic foundation if their oncologic sufferers or sufferers liable to melanoma may well really reap the benefits of a nutrition enriched in omega-3 PUFAs or from a nutritional supplementation with those fatty acids. The e-book represents additionally an excellent source for traditional participants in addition to melanoma sufferers to benefit extra approximately omega-3 PUFAs and know the way those nutritional elements may perhaps impact melanoma progress.

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Extra resources for Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer

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Cancer Res. 2001; 61:2759–2765. 49. Friesen C, Fulda S, Debatin KM. Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells. Leukemia. 1997; 11:1833–1841. 50. Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME et al. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem. 1998; 273:33942–33948. 51. Biondo PD, Brindley DN, Sawyer MB, Field CJ. The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy.

Cardiolipin rich in ω-3 PUFAs is more susceptible to ROS, and peroxidation results in an altered composition and reduced mitochondrial membrane integrity [81]. This then compromises energy metabolism [81], which in turn initiates apoptosis [83]. Indeed, cardiolipin hydroperoxides have been shown to directly trigger the release of pro-apoptotic factors from mitochondria [84]. Although there is considerable evidence for membranes rich in ω-3 PUFAs to make cells more susceptible to the production of pro-apoptotic ROS, there are still many questions to answer.

They further examined effects of PUFAs on these proteins and found that cyclin B1 phosphorylation was decreased. EPA and DHA inhibited growth of the SW1990 pancreatic cancer cell line in a timeand concentration- dependent manner. This effect appeared to be due to increased cyclin E mRNA [177]. In summary, studies have demonstrated that ω-3 PUFAs, particularly DHA, arrest malignant growth, usually in the S phase, and prevent G1/S progression in a variety of cell types (reviewed by [39]). In the cell lines that demonstrated reduced growth with ω-3 PUFAs, the fatty acid treatment appeared to alter the levels of cyclins, cyclin -dependent kinases, and pRB.

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Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer by Michael B. Sawyer, Catherine J. Field (auth.), Gabriella Calviello, Simona Serini (eds.)


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