By Joel E. Tepper, Leonard L. Gunderson
First Prize winner, Oncology publication class, British clinical organization 2012 scientific booklet Competition
• Deepen your wisdom with a finished, medical method of the clinical foundations of radiation oncology and basic oncology in addition to cutting-edge thoughts and modalities.
• enforce a multidisciplinary, "team care" method of supplying tricky treatment options for sufferers, usually at the side of scientific oncologists, and surgeons.
• develop your realizing of the fundamental biology of the illness processes.
• research the healing administration of particular disorder websites in accordance with single-modality and combined-modality approaches.
• quick and simply locate serious info because of an simply obtainable, full-color layout with over 800 colour figures that basically depict remedy strategies.
• Get large multimodality views and designated insights from a various staff of revered editors and participants -many of whom are new to this version - affiliated with associations throughout North the US and across the world
• entry the totally searchable textual content anyplace, every time at www.expertconsult.com, besides references, extra pictures and tables, videos and more!
• remain present with accomplished updates all through that come with a brand new bankruptcy on survivorship concerns, and extra videos on remedies reminiscent of prostate and penile melanoma brachytherapy.
• increase results by way of supplying the best remedy for every sufferer with elevated assurance of latest modalities and remedy regimens.
• comprehend and conform to the newest staging guidelines.
Drs. Gunderson and Tepper offer you easy accessibility to the entire medical instruments you must grasp the latest options and modalities in radiation oncology.
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Extra info for Clinical Radiation Oncology (3rd Edition)
5 Gy) 14 16 18 20 Figure 1-21 Representative survival curves for cells irradiated with x rays in the presence (aerobic) or virtual absence (hypoxic) of oxygen. 05. DNA-sensitizer • Figure 1-22 Schematic representation of the proposed mechanism of action for the oxygen effect. The radical competition model holds that oxygen acts as a radiosensitizer by forming peroxides in DNA already damaged by radiation, thereby fixing the damage. In the absence of oxygen, DNA can be restored to its preirradiated state by hydrogen donation from endogenous reducing species in the cell, such as the free radical scavenger glutathione.
In a more practical sense, this means that a multifraction survival curve can be generated using the formula SFn = (SF1)n, where SF1 is the surviving fraction of cells after one dose fraction (determined from a single-dose survival curve or comparable assay) and SFn is the surviving fraction of cells after n dose frac tions. Accordingly, multifraction survival curves are shoulderless and exponential (Figure 1-11). 5. Sublethal damage recovery is largely responsible for the “dose-rate effect” for low LET radiation, which will be discussed in detail later in this chapter.
An oxygen-mimetic, hypoxic cell radiosensitizer may be used to substitute for oxygen in these fast, free radical reactions, or an exogenously supplied thiol compound may be used to act as a radioprotector. 0 Range of normal tissue PO2 10 20 30 40 50 60 70 155 Oxygen tension (mm Hg at 37° C) 760 Figure 1-23 An oxygen k-curve illustrates the dependence of radiosensitivity on oxygen concentration. 0. 0). The green-shaded area represents the approximate range of oxygen concentrations encountered in human normal tissues.
Clinical Radiation Oncology (3rd Edition) by Joel E. Tepper, Leonard L. Gunderson