By Abraham, Jame; Allegra, Carmen J.; Gulley, James L
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Extra resources for Clinical Oncology
2009;53(3):520-523. 20. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953;6:963-968. 21. The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324:1685-1690. 22. Van Waes C. Head and neck squamous cell carcinoma in patients with Fanconi anemia.
Surgical resection of the primary tumor with left neck dissection followed as needed by chemoradiation is the treatment of choice B. This represents one of a minority of head and neck cancers in which a strong association with EBV has not been established C. The recommended treatment is concurrent cisplatin chemotherapy and radiation followed by adjuvant cisplatin and 5-FU chemotherapy D. With this stage and grade of disease, 5-year overall survival is typically about 20% E. Both C and D 4. A 62-year-old woman presented with a 2 cm oropharyngeal squamous cell carcinoma (base of tongue) with spread to a 6 cm lymph node spanning left levels II and III.
7th ed. New York: Springer-Verlag; 2010. 9. Freudlsperger C, Burnett JR, Friedman JA, Kannabiran VR, Chen Z, Van Waes C. EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy. Expert Opin Ther Targets. 2011;15(1):63-74. 10. Fury MG, Pfister DG. Current recommendations for systemic therapy of recurrent and/or metastatic head and neck squamous cell cancer. J Natl Compr Canc Netw. 2011;9:681-689. 11. Langendijk JA, Bourhis J. Reirradiation in squamous cell head and neck cancer: recent developments and future directions.
Clinical Oncology by Abraham, Jame; Allegra, Carmen J.; Gulley, James L