By England 1958 Wolstenholme, G. E. W. ; O'Connor, Cecilia M. Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity London
Chapter 1 Chairman's starting feedback (pages 1–4): F. Bergel
Chapter 2 The Stereochemistry of evidently taking place ??Amino Acids (pages 5–18): ok. Balenovic
Chapter three The Mode of motion of Chloramphenicol (pages 19–37): E. F. Gale
Chapter four A initial examine of the impression of Amino Acid Deficiencies on Experimental melanoma Chemotherapy (pages 38–61): Howard E. Skipper and J. Richard Thomson
Chapter five a few facets of Azaserine, 6?Diazo?5?Oxo?1?Norleucine and ??2?Thienylalanine (pages 62–74): H. Christine Reilly
Chapter 6 The Interference of Azaserine in Purine Biosynthesis (pages 75–88): John M. Buchanan
Chapter 7 Amino Acid and Peptide Derivatives with capability Antitumour homes (pages 89–103): J. A. Stock
Chapter eight scientific results of Amino Acids wearing Nitrogen Mustard teams (pages 104–109): Eve Wiltshaw and D. A. G. Galton
Chapter nine additional scientific Observations on p?Di(2?Chloroethyl)Amino?DL?Phenylalanine (Sarcolysine) compared to another Chloroethylamine Derivatives (pages 110–122): Natalia I. Perevodchikova and N. N. Blokhin
Chapter 10 contemporary advancements in Actinomycin Chemistry (pages 123–137): A. W. Johnson
Chapter eleven medical and organic experiences with Actinomycins (pages 138–148): S. Farber
Chapter 12 The Chemistry of Etamycin (pages 149–156): John C. Sheehan, Hans Georg Zachau and William B. Lawson
Chapter thirteen The Aminoagyl Insertion response and Peptide Chemistry (pages 157–170): M. Brenner
Chapter 14 Synthesis of Cyclic Polypeptides (pages 171–191): R. Schwyzer
Chapter 15 Disulphide Crosslinking in Cysteine Peptides (pages 192–204): H. N. Rydon
Chapter sixteen constitution and serve as of a few Sulphur?Containing Peptides (pages 205–225): E. P. Abraham and G. G. F. Newton
Chapter 17 Bacitracin (pages 226–246): Lyman C. Craig, William Konigsberg and Robert J. Hill
Chapter 18 Oxidative Formation of Biologically lively Compounds from Peptides (pages 247–276): A. J. Birch and Herchel Smith
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Additional info for Ciba Foundation Symposium - Amino Acids and Peptides with Antimetabolic Activity
Work: No, rather that the amino acid coupled to its initial acceptor is reactive and that it may react with other cell components in a nonspecific manner. It seems to me this was almost suggested by the variations from amino acid to amino acid. Gale: One cannot answer that, but at the moment I would like to work on the hypothesis that this is an association between an activated amino acid and some form of acceptor; whether there is a specificity between the acceptor and the amino acid we have yet to find out.
The question is: are nucleic acid and protein synthesis two parts of one reaction or two different processes from common precursors? Work: This result may be misleading because it looks as if chloramphenicol may cause accumulation of intermediates which are presumably reactive. Under the conditions you are using I should have thought there was considerable danger that each amino acid, linked to some reactive intermediate, was a t a different degree of reactivity and just tended to react with different portions of the cell according to what its reactivity was.
C . , and GROS,F. (1957). Biochim. biophys. Acta, 25,513. PARDEE, A. , and PRESTIDGE, L. S. (1957). Biochim. biophys. Acta, 23, 162. PARDEE, A. , and PRESTIDGE, L. S. (1956). J . , 71,677. PARK, J. , and STROMINGER, J. L. (1957). Science, 125,99. J. (1953). Biochem. , 55,441. SHEPHERD,C. J. (1958). I n preparation. SMITH,G. N. (1953). Bact. ,17,19. SMITH,G. , WORREL,C. , and SWANSON, A. L. (1949). J. , 58, 803. M N O ACIDS-2 34 E. F. GALE STRAUB, F. , and ULLMAN, A. (1957). Biochim. biophys. Acta, 23,665.
Ciba Foundation Symposium - Amino Acids and Peptides with Antimetabolic Activity by England 1958 Wolstenholme, G. E. W. ; O'Connor, Cecilia M. Ciba Foundation Symposium on Amino Acids and Peptides with Antimetabolic Activity London