Ciba Foundation Symposium 197 - Variation in the Human by PDF

ISBN-10: 0470514884

ISBN-13: 9780470514887

ISBN-10: 0471961523

ISBN-13: 9780471961529

The mapping of human genes is continuing swiftly. Genes linked to particular inherited illnesses are being pointed out, frequently offering perception into the molecular reason behind the disorder. in the interim, even though, little attention is being given to the difference found in various human populations. edition within the Human Genome discusses equipment of analysing inhabitants genetic facts and the way modern genetic heterogeneity arises throughout the evolution and migration of human populations. particular problems equivalent to cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour improvement susceptibility are used to demonstrate this genetic variability and mechanisms of gene mutation and evolution.

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It seems likely that many of the qualitative effects on genealogy of geographical population structure may nonetheless hold for other forms of spatial structure, although at this stage little has been established. If the migration rates are high enough, gene trees from any of the spatial models under consideration will resemble those from panmictic populations. For lower migration rates, the effect of the spatial structure, loosely speaking, is opposite to that of population growth. That is, gene trees tend to be compressed near their tips and stretched near their root.

Annu Rev Genet 29:401-421 Ewens WJ 1990 Population genetics theory-the past and the future. In: Lessard S (ed) Mathematical and statistical developments of evolutionary theory. Kluwer Dordrecht, Amsterdam, p 177-227 Excoffier L 1990 Evolution of human mitochondria1 DNA: evidence for departure from a pure neutral model of populations at equilibrium. J Mol Evol 30: 125-1 39 Griffiths RC, Tavark S 1994a Sampling theory for neutral alleles in a varying environment. Phil Trans R SOCLond B Biol Sci 344:403410 Griffiths RC, Tavark S 1994b Ancestral inference in population genetics.

1996 Variation in the human genome. Wiley, Chichester (Ciba Foundation Symposium 197) p 25-50 Patterns in genetic data result from the superposition of two random mechanisms. The first is the underlying genealogical tree, which describes the ancestral history of the sampled genes. The second is the effect of mutation in changing genetic types. In non-neutral models these two forces interact: the action of mutation on genetic type in turn affects the structure of the genealogical tree as a consequence of natural selection.

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Ciba Foundation Symposium 197 - Variation in the Human Genome


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