Download PDF by Alessandra Pani: Cell Growth and Cholesterol Esters

By Alessandra Pani

ISBN-10: 0306482363

ISBN-13: 9780306482366

This quantity is dedicated to melanoma and atherosclerosis, of crucial proliferative pathologies on the earth this day. This e-book presents an invaluable element of reference at the mechanisms that hyperlink ldl cholesterol esters to telephone proliferation, summarizing the most recent advances either in uncomplicated technological know-how and scientific examine. This e-book can be of undoubted worth to biomedical scholars and lecturers, in addition to these actively engaged in study on ldl cholesterol metabolism, melanoma, and atherosclerosis.

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Sample text

Ras proteins are initially synthesized as precursor proteins and are found in the cytoplasm of cells. • Within minutes, they undergo a series of CAAX-signaled posttranslational modifications that promote translocation and stable association with the inner surface of the plasma membrane. • Ras first undergoes farnesylation (covalent addition of the 15-carbon farnesyl group, via a thioether linkage from the C1 carbon to the thiol of the cysteine residue of CAAX box). The cytosolic farnesyltransferase (FTase) enzyme catalyzes this reaction using farnesyl diphoshate (FPP) and the CAAX box as cosubstrates.

Endogenous cholesterol Low-density lipoprotein (LDL) Derived from VLDL. Transports cholesterol to peripheral tissues. Endogenous cholesterol High-density lipoprotein HDL2 and HDL3 Derived from nascent HDL as a result of the acquisition of cholesterol esters by LCAT. Involved in "reverse transport" of cholesterol from cells to the liver. Excess cholesterol vary in their function, densities, size and triglyceride/cholesterol ester ratios: VLDL, IDL, LDL and HDL. 1). Lipoproteins are composed of a neutral core of cholesterol esters and triglycerides.

The apoproteins are specific proteins attached to lipids. They have a variety of functions in aiding in the metabolism of lipids which includes: • To provide structures for facilitation of transport out of the intestine and liver; • To provide recognition sites for cell-surface receptors; • To act as cofactors for enzymes involved in metabolism of lipoproteins. 2 shows the main apoproteins, their lipoprotein association and function. Chylomicrons are assembled in the intestinal mucosa as a means to transport dietary cholesterol and triglycerides to the rest of the body.

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Cell Growth and Cholesterol Esters by Alessandra Pani


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