By Edward S. Greenwald (Auth.)
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221. CHAPTER II ALKYLATING AGENTS The alkylating agents are the single most useful group of cancer chemotherapeutic a g e n t s . Despite this, there is little evidence that they prolong survival significantly. Studies with cyclophosphamide in multiple myeloma indicate that life is lengthened. I am not aware of similar s t u d i e s with alkylating agents in other malignancies. There has been a great deal of controversy a s to whether there are b a s i c differences among the various alkylating a g e n t s .
Mechlorethamine has been used extensively in lymphosarcoma. However, chlorambucil is probably safer and possibly more effective in small cell lymphosarcoma and its c l o s e relative, chronic lymphatic leukemia. The same holds true for giant follicular lymphoblastoma. Mycosis fungoides has been successfully treated with mechlorethamine. 1 6 " 1 8 However, remissions tend to be very brief (usually l e s s than three months). Repeat courses may be as successful a s the first, but eventually r e s i s t a n c e develops.
22. : Actinomycin and its Effects: Influence on an Effector Pathway for Hormonal Control. New Eng. J. Med. 271:1252, 1301, 1964. 23. : Mode of Action of Antibiotics. II. Drugs Affecting Nucleic Acid and Protein Synthesis. Am. J. Med. 39:722, 1965. 24. A. Chemotherapy of Cancer, Amsterdam, London, New York, E l s e v i e r Publishing Company, 1964, p. 191. 25. : A Methylhydrazine Hodgkin's Disease and Other Malignant Neoplasms. Med. 63:69, 1965. Derivative in Ann. Intern. 26. : Contributions to the Biological and Clinical Effect of a Methylhydrazine Derivative.
Cancer Chemotherapy by Edward S. Greenwald (Auth.)