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By Wai Yiu Cheung

ISBN-10: 0121714063

ISBN-13: 9780121714062

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Difficulties encountered in inhibition studies of myosin light chain kinase may relate to these effects. For example, Perry (1980) found that inhibition of the enzyme by troponin I is less than expected, while Katoh et al. (1982) reported that the inhibition by melittin is reversed by increasing concentrations of the substrate. Since excess concentrations of the myosin light chain ( ^ 1 0 μΜ) are used in these assays, the fraction of peptide or protein bound by it can be substantial. The peptide-binding properties of troponin C are consistent with the belief that it is the protein most like calmodulin.

Roc. Natl. Acad. Sei. USA 82, 4 3 7 9 - 4 3 8 3 . 42 Sonia Ruth Anderson and Dean A. , and Weiss, Β. (1982). Interaction of ß-endorphin and other opioid peptides with calmodulin. Mol. Pharmacol. 2 1 , 8 6 - 9 1 . , and Weiss, B. (1984). Interaction of various peptides with calmodulin. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 2 6 1 - 2 7 6 . Snyder, S. , and Innis, R. B. (1979). Peptide neurotransmitters. Annu. Rev. Biochem. 48, 7 5 5 782. Talbot, J. , and Hodges, R. S. (1981). Synthetic studies on the inhibitory region of rabbit skeletal troponin I.

Acad. Sei. USA 82, 4 3 7 9 - 4 3 8 3 . 42 Sonia Ruth Anderson and Dean A. , and Weiss, Β. (1982). Interaction of ß-endorphin and other opioid peptides with calmodulin. Mol. Pharmacol. 2 1 , 8 6 - 9 1 . , and Weiss, B. (1984). Interaction of various peptides with calmodulin. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 2 6 1 - 2 7 6 . Snyder, S. , and Innis, R. B. (1979). Peptide neurotransmitters. Annu. Rev. Biochem. 48, 7 5 5 782. Talbot, J. , and Hodges, R. S. (1981). Synthetic studies on the inhibitory region of rabbit skeletal troponin I.

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Calcium and Cell Function by Wai Yiu Cheung


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