Read e-book online Antibody-Drug Conjugates PDF

By Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

ISBN-10: 1627035400

ISBN-13: 9781627035408

Antibody-drug conjugates (ADCs) signify a promising healing strategy for melanoma sufferers through combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic efficiency of chemotherapeutic medications. In Antibody-Drug Conjugates, professional researchers supply certain protocols for lots of of the major ADC innovations useful for operating within the box. those chapters and methodologies are geared toward the major projects essential to establish an appropriate goal, competently layout the mAb, the linker and the payload, in addition to to conjugate them in a reproducible and scalable model. Written within the hugely winning Methods in Molecular Biology™ layout, those exact chapters comprise the type of useful implementation suggestion that promises caliber results.

Authoritative and well timed, Antibody-Drug Conjugates goals to additional force ADC improvement and hence aid towards enhancing melanoma remedies of the future.

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J Clin Oncol J Am Soc Clin Oncol 30:2190–2196 39. Senter PD, Sievers EL (2012) The discovery and development of brentuximab vedotin for 24 Ingrid Sassoon and Ve´ronique Blanc use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Nat Biotechnol 30:631–637 40. Francisco JA, Cerveny CG, Meyer DL et al (2003) cAC10-vcMMAE, an anti-CD30monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 102:1458–1465 41. Younes A, Bartlett NL, Leonard JP et al (2010) Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas.

Sauter A, Kloft C, Gronau S et al (2007) Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck. Int J Oncol 30:927–935 11. Tijink BM, Buter J, Bree R et al (2006) A phase I dose escalation study with antiCD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res J Am Assoc Cancer Res 12:6064–6072 12. Lapusan S, Vidriales MB, Thomas X et al (2012) Phase I studies of AVE9633, an antiCD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia.

In general, these antigenic targets are about as tumor specific as one can get in the ADC field. Another consideration in the realm of specificity is whether target-positive normal tissue subject to ADC binding is necessary to support/maintain life and/or whether the tissue can regenerate. Clearly, in the case of PSMA, if renal or bowel toxicity were to occur, it would be problematic; conversely, prostatic loss may not be a problem (except perhaps where fertility was important). In other cases, loss of normal cells can be tolerated particularly if they subsequently repopulate as in the case of CD20-pos normal lymphocytes.

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Antibody-Drug Conjugates by Ingrid Sassoon, Véronique Blanc (auth.), Laurent Ducry (eds.)

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