By Robin Holliday (auth.)
For centuries humans were wondered by means of the inevitability of human getting older. for many of the second one half the 20 th century getting older remained a secret, or an unsolved organic challenge. on the finish of the 20 th century a impressive clinical discovery emerged. It was once no longer a unmarried discovery within the traditional experience, since it was once in response to a chain of significant interconnected insights over relatively a protracted time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it might probably already be stated, in spite of the fact that, that the numerous observations and insights that designate getting older aren't authorized as confirmed wisdom for a very long time. the sphere continues to be choked with scientists, and non-scientists, who're simply satisfied to move on speculating in regards to the "mystery" of getting older. the purpose of this booklet is to dispel lack of knowledge via explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of life.
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Additional info for Aging: The Paradox Of Life: The biological reasons for aging are now well understood
The fact that one organ-system fails first, should not blind us to the fact that there is a multiplicity of changes occurring in molecules, cells, tissue and organs during ageing. Chapter 5. The Ancient Origins of Ageing Not all organism age. It is well established that populations of bacteria or yeast can go on growing forever, as long as nutrients are provided. Many plants reproduce vegetatively (or asexually), by forming tubers, bulbs or corms, or they can be propogated by cuttings. Thus, the continuous growth of complex living organisms such as plants is perfectly possible.
Obviously this has serious deleterious effects. Examples of autoimmunity increase with ageing, and a particularly painful example is osteoarthritis, or degenerative joint disease. However, osteoarthritis can also be caused by mechanical wear and tear of joints, which is very common in aged people. We should also note that the alterations in normal proteins during ageing may generate molecules that the immune system sees as non-self, and as a consequence there is an autoimmune reaction. One example of efficient repair is the removal of damage in DNA in all the cells of our body (except red blood cells).
This global overview is that ageing is due to the eventual failure of maintenance. Maintenance is essential for normal development to the adult and for the several decades of adult life. After that things start to go wrong, as we are no longer able to sustain the 36 Chapter 4 status quo. Eventually the complexity and order that characterises life itself is lost, and death follows. On our death certificate a single cause of death may be given, but the reality is that if we did not die from one cause, we would die from another.
Aging: The Paradox Of Life: The biological reasons for aging are now well understood by Robin Holliday (auth.)